Dr. Tae Park gave one gram of IV gamma globulin in 500 cc of normal saline infused over 1 hour once a week to 50 CFS patients for six months, none of whom were working at the time. He also monitored their sleep, prescribing Klonopin and/or Prozac (10-20 mg.) if needed, and their activity levels and diet, accentuating organic foods and avoiding bread, canned foods, chocolate, MSG, aspartame and hot pepper. His patients were instructed to drink 2-3 liters of water a day with 2-3 teaspoons of salt, and walk no more than I hour a day.His patients did very well; most returned to work or school, Karposky scores rose from the 40’s to the 80’s or 90’s and their cognition improved. Importantly, problems with sleep apnea improved greatly. Some of the younger patients essentially recovered in one to two months. Three to five years later Dr. Park said these patients still maintained their near complete recovery. A Talk With Dr. Park - In his poster Dr. Park noted several IV gamma globulin trials that have failed in the past. I asked him in an e-mail why he thought his trial has worked while others had failed.He said that he believes that CFS physicians and their patients underestimate how important it is to have a toxic free environment. He believes that an increasingly toxic environment is a main contributor to CFS; that it is the toxins we are exposed to in our air, foods and water that disrupt our immune systems allowing latent virus reactivation. He prohibits his patients from living in newly built houses. He stated he often sees enlarged livers (and noted, to his surprise, that few physicians in the U.S. know how to ‘palpate’ livers.)Gamma globulin is the most important agent he has to treat central nervous system inflammation. He notes that many of his CFS patients present with stroke-like or Parkinson’s-like symptoms and sleep apnea even after using CPAP and all of them show improvement with intravenous gamma globulin. Three to six months of IV gamma globulin has also been effective in improving the low renal blood flows noted in Dr. Park’s poster (in the IACFS I: Cardiovascular and Exercise Studies click here). As described in that poster Dr. Park believes that CFS is a disease characterized by systemic microvascular inflammation.