Research evidence indicates diminished mitochondrial function which may be due to high rates of oxidation in persons with Chronic Fatigue Syndrome (PWCs).  Mitochondria are the cellular engines which produce energy.  Once mitochondrial function is impaired, the energy available for cells to perform their various functions becomes limited.  This can impact many biological systems including cognitive function, detoxification, and immunity.  There are various substances and conditions that can damage the mitochondia including damage to the mitochondrial lipid membrane. 

A report in the Spring 2006 edition of the Journal of Chronic Fatigue Syndrome described clinical studies where lipid replacement therapy (LRT) combined with antioxidants appeared to reduce fatigue levels and improve mitochondrial function by protecting the membranes and replacing damaged lipids(also know as lipid replacement therapy or LRT).  I can personally attest to the effectiveness of a similar therapy.  For antioxidants I take a product called Oasis Xtra which has a very high ORAC (oxygen radical absorbtion capability), and for lipid replacement I take phosphatidyl choline (PC), and Evening Primrose Oil.  It took several months before I noticed an improvement, but it was key in my recovery.

Other’s, incuding Dr. Garth Nicolson, recommend the use of NTFactor and Propax to help limit mitochondrial damage and to repair the cell membranes. 

In clinical studies, subjects using dietary LRT and antioxidants experienced a 40 percent reduction in fatigue scores after eight weeks. Researchers also observed a correlation between reductions in fatigue and gains in mitochondrial function.