Lyme Disease, both in acute and chronic form, is a terribly difficult illness to diagnose with standard blood tests.  Thus, the political debate over who has it, who doesn’t, or if it even exists rages on.  All the while the patient’s, who are clearly ill, still continue to suffer. 

Medical textbooks agree that Lyme Disease remains a clinical diagnosis.  This means that your doctor has to look at your symptoms, history and blood work to make a diagnosis.  It doesn’t mean that a diagnosis should be made on the results of blood work alone. 

Sympomology is extremely important.  Here is the long list of symptom presentation of Lyme Disease:

Musculoskeletal/rheumatologic

Joint pain

Muscle pain and cramps

Muscle and joint stiffness

Reduced mobility

Loss of muscle tone

Back pain, stiffness

Neck pain, stiffness

Vertebral disc disease

Temporomandibular joint syndrome

Neurologic

Neuropathies

Encephalopathy

Paresthesias

Dizziness, vertigo

Cognitive disturbances

Cranial nerve disturbances

Attention deficit/Autism

Hypersensitivity to touch, sound, light, smell

Bell’s palsy

Tinnitus

Restless legs syndrome

Drooping eyelid

Transient blurred vision

Clumsiness

Depression

Insomnia, fatigue

Difficulty chewing or swallowing

Hallucinations

Headaches

Involuntary jerking or muscle twitching

Irritability

Poor balance

Sleep disturbances

Speech difficulty

Weakness of limbs

Cardiac

Palpitations

Arrhythmias

Shortness of breath

Tachycardia

Hypotension

Hypertension

New-onset heart murmur

New-onset chest pain

Abnormal ECG

Chest pain, tightness

Psychiatric (all new-onset)

Anxiety

Panic disorder

Irritability

Depression

Bipolar disorder

Obsessive-compulsive disorder

Endocrinologic

Low body temperature

Night sweats, chills

Symptoms of adrenal insufficiency (fatigue, muscle weakness, loss of
appetite, weight loss)

Flushing

Irregular menses

Loss of libido

Worsening premenstrual syndrome

Menstrual irregularities

Milky nipple discharge

Hypertriglyceridemia

New-onset hypothyroidism

Weight change (usually gain)

Gastrointestinal/urogenital

Abdominal pain and tenderness

Bloating, gas

Constipation

Food allergies

Urinary/bowel control problems

Nausea

Irritable bladder

Excessive thirst

Dysuria, polyuria, hematuria

Testicular/pelvic pain

Dyspareunia

Other

Easy bruising

Hair loss

Recurrent sinusitis

Sore throat

Tender glands

Tooth pain

Unusual rashes

Shooting pains throughout body

Sources: Burrascano. Advanced topics in Lyme disease. 2005

Rubel. Lyme disease symptoms and characteristics. 2005-2006